Orders that are shipped to a different address than the billing address.
Orders from foreign countries
Orders on US cards shipped to foreign countries
Billing addresses that don't match the information on file with the credit card company.
By themselves, no one of these things are a sure sign that a credit card is stolen, but when several factors are present (say, your average ticket amount is $75 and you see an rush order for $5,000 being shipped to a different address than the address of the credit card holder) it's prudent to be suspicious and investigate the sale.
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Even if there's only one factor that doesn't pass your "sniff" test Wholesale Cigarettes Online, it's useful to err on the cautious side. As an example, not long ago, someone using a credit card with US address purchased a product from us and wanted it shipped to someone by a different name in another country. The particular product was one that wouldn't be a lot of use to anyone in the country it was being shipped to, so we called the credit card holder to verify the shipping address. The credit card holder hadn't made the purchase. Then, verify the information you are given by calling the merchant bank or using whatever other address verification system is in place through the ISO that processes your charges. If the address you were given doesn't match the address of the cardholder, don't ship.